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Cat. No. | Product Name | Target | Signaling Pathways |
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T36382 |
all-trans-5,6-epoxy Retinoic Acid
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all-trans-5,6-epoxy Retinoic Acid 可用于生命科学领域的相关研究。其产品编号为 T36382,CAS号为 13100-69-1。 | |||
T67921 |
Retinoic acid-d5
all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 |
Retinoid Receptor | Metabolism |
Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂, 对 RARα/β/γ 的 IC50 为 14 nM,与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物,在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。 | |||
T6694 |
Tamibarotene
NSC 608000,Am 80,Amnolake,他米巴罗汀 |
Apoptosis; Retinoid Receptor; Autophagy | Apoptosis; Autophagy; Metabolism |
Tamibarotene (Amnolake) 是一种具有口服活性的合成维甲酸,旨在克服全反式维甲酸耐药性,具有潜在的抗肿瘤活性。它也是视黄酸受体α/β 的激动剂,比RARγ的选择性高。 | |||
T7370 |
Talarozole
R115866,他拉罗唑 |
Others; P450; Retinoid Receptor; Autophagy | Autophagy; Metabolism; Others |
Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂,可抑制 CYP26A1 和 CYP26B1,IC50 分别为 5.4 和 0.46 nM。它用于治疗痤疮、牛皮癣和其他角化疾病。 | |||
T35952 |
all-trans Retinoyl β-D-Glucuronide
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all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration. | |||
T13422L |
Talarozole (R enantiomer)
(R)-Talarozole,Talarozole R enantiomer |
Others | Others |
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid. | |||
T25716L |
Liarozole HCl
R75251,Liarozole hydrochloride,R 75251,R-75251 |
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Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an increase in endogenous ATRA production, | |||
T39703 |
ATRA-biotin
ATRA-biotin,Biotin-ATRA-conjugate |
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ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues. | |||
T78102 |
ER 50891 quarterhydrate
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ER 50891 quarterhydrate为效效的视黄酸受体α(RARα)拮抗剂,可显著削弱ATRA对BMP 2诱导成骨细胞生成的抑制效果。 | |||
T35687 |
Collismycin A
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Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc... | |||
T35629 |
ATRA-BA Hybrid
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ATRA-BA hybrid is a mutual prodrug form of all-transretinoic acid and butyric acid .1ATRA-BA hybrid is cleaved to release ATRA and BA in isolated mouse plasma. It inhibits the growth of MDA-MB-231 breast and PC3 prostate cancer cells with GI50values of 0.01 and 1.02 μM, respectively. ATRA-BA (20 μM) has 15-fold greater antiproliferative activity in PC3 cells compared to an equimolar concentration of ATRA and BA. 1.Gediya, L.K., Khandelwal, A., Patel, J., et al.Design, synthesis, and evaluation o... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7408 |
all-trans-4-Oxoretinoic acid
4-KETO全反式维甲酸,all-trans 4-Keto Retinoic Acid |
Endogenous Metabolite | Metabolism |
all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) 是一种维生素A 的特性代谢物,能够通过作用核维甲酸受体(RARs) 来诱导基因转录。 | |||
T1051 |
Retinoic acid
维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin |
Retinoid Receptor; Endogenous Metabolite; PPAR; Autophagy | Autophagy; DNA Damage/DNA Repair; Metabolism |
Retinoic acid (Tretinoin) 是维生素 A 的代谢产物,是一种视黄酸受体 RAR 的天然激动剂,抑制 RARα/β/γ (IC50=14 nM)。Retinoic acid 可以诱导细胞分化、减少细胞增殖和抑制肿瘤发生。 | |||
T36417 |
Nargenicin
Antibiotic 47444 |
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Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (... |